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Tamiflu

Generic name: Oseltamivir phosphate
Brand names: Tamiflu
Why is Tamiflu prescribed?
User Reviews & RatingsAs a treatment for... Avg User Ratings [?]
Swine Influenza
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Tamiflu speeds recovery from the flu. When started during the first 2 days of the illness, it hastens improvement by at least a day. It also can prevent the flu if treatment is started within 2 days after exposure to a flu victim. Tamiflu belongs to a class of antiviral drugs called neuraminidase inhibitors.

As the flu virus takes hold in the body, it forms new copies of itself and spreads from cell to cell. Neuraminidase inhibitors fight the virus by preventing the release of new copies from infected cells. Tamiflu is taken in liquid or capsule form.
Most important fact about Tamiflu

Tamiflu can prevent the flu as long as you continue taking Tamiflu, but getting a yearly flu shot is still the best way of avoiding the disease entirely. For older adults, those in high-risk situations such as health-care work, and people with an immune deficiency or respiratory disease, vaccination remains a must.
How should you take Tamiflu?

To provide any benefit, Tamiflu must be started within 2 days of the onset of symptoms, or exposure to the flu. If you have the flu, continue taking it twice daily for 5 days, even if you start to feel better. To prevent the flu, take it once a day for at least 7 days. Protection lasts as long as you take the drug.

If Tamiflu upsets your stomach, try taking it with food. Shake the liquid suspension before each use.
If you miss a dose...
Take it as soon as possible. If it is within two hours of your next dose, skip the missed dose and go back to your regular schedule.
Storage instructions...
Store at room temperature. Keep the blister package dry. Use the liquid suspension within 10 days. It should be refrigerated, but do not freeze.
What side effects may occur?

Most problems noted during tests of Tamiflu were indistinguishable from the symptoms of flu. Here are the reactions that showed up more frequently in patients taking the drug.
Side effects may include:
Abdominal pain, asthma, bronchitis, cough, diarrhea, ear infection, fatigue, headache, insomnia, nausea, nosebleed, vertigo, vomiting
Why should Tamiflu not be prescribed?

If Tamiflu gives you an allergic reaction, avoid it in the future.


Special warnings about Tamiflu

If you have kidney disease, the doctor may have to cut your daily dose of Tamiflu in half.

The effectiveness of Tamiflu has not been established for people with weakened immune systems. The drug has not been studied in people with liver disease.

Tamiflu works only on the flu virus. It won't stop bacterial infections that may have flu-like symptoms or bacterial infections that may develop while you have the flu. If your symptoms persist, check with your doctor.

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The effectiveness of Tamiflu 75 mg for preventing influenza, dosing regimen

Tamiflu is indicated for the prevention of influenza in adults and children over 1 year.

Tamiflu does not replace the annual early vaccination as recommended by the Committee on Immunization tactics Centers for Disease Control.

The effectiveness of Tamiflu for prevention of natural influenza infection was demonstrated in three seasonal prophylaxis studies and a study on post-exposure prophylaxis in the home. The main parameter of efficiency in all these studies was the incidence of laboratory podtverdennoy clinical influenza infection. Clinical laboratory confirmed influenza infection was defined as the temperature in the oral cavity 37.2 ° C plus at least one respiratory symptom (cough, sore throat, nasal congestion) and at least one symptom of the general condition (pain, weakness, headache, chills and sweating ), all of which must be fixed within 24 hours, plus either isolation of the virus, or an increase antiviral antibody titer of not less than 4 times higher than baseline.

In summary, the analysis of two seasonal prophylaxis studies conducted in healthy unvaccinated vzrosly (aged 13 to 65 years), the use of Tamiflu 75 mg 1 time a day for 42 days during the epidemic in this area has reduced the incidence of laboratory confirmed clinical influenza with 4.8% (25/519) in the placebo group to 1.2% (6 / 520) in the group of Tamiflu, the difference was 76%.

In a study of seasonal prophylaxis in elderly residents of a specialized nursing home use of Tamiflu 75 mg 1 time a day for 42 days reduced the incidence of laboratory confirmed clinical influenza from 4.4% (12/272) in the placebo group to 0.4% (1 / 276) Tamiflu group (difference 92%). About 80% of this population of elderly persons had previously been vaccinated, 14% of study participants had chronic obstructive pulmonary disease, 43% - heart disease.

In a study of post-exposure prophylaxis after household contacts (from age 13 years) with a sick person the use of flu Tamiflu 75 mg 1 time a day, beginning no later than 2 days from the onset of symptoms in a sick relative, and then for 7 days , reduced the incidence of laboratory confirmed clinical influenza infection 12% (24/200) in the placebo group to 1% (2 / 205) in the Tamiflu group (difference 92%). Primary sick in this study had not received Tamiflu.

The standard dosing regimen.

The recommended dose of Tamiflu 75 mg for oral administration for prevention of influenza following close contact with an infected person is 75 mg 1 time per day for at least 7 days. Receiving the drug should be started within 2 days of contact. The recommended dose for prophylaxis during epidemics of influenza in the area is 75 mg 1 time per day. The efficiency and safety of the drug at the reception for up to 6 weeks. A preventive effect of influenza is preserved for all time reception.

For instructions on dosing in special cases:

In patients with creatinine clearance of 10 to 30 ml / min is recommended correction prophylactic dose of Tamiflu 75 mg. These patients are recommended to reduce the dose of Tamiflu to 75 mg every other day. Recommendations on dosing regime for patients receiving chronic hemodialysis and chronic peritoneal dialysis at the stage renal disease does not exist.

Patients childhood.

The efficiency and safety of the drug for prophylaxis in children older than 1 year.

Children older than 1 year
The recommended dosing regimen of Tamiflu suspension for oral administration: weight recommended dosage for 10 days
? 15 kg 30 mg 1 time per day
> 15 - 23 kg 45 mg 1 time per day
> 23 - 40 kg to 60 mg 1 time per day
> 40 kg, 75 mg 1 time per day
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Indications: Tamiflu - the antiviral drug which is effective in treating influenza virus h1n1

Recommended by the World Health Organization (WHO) for the treatment and prevention of influenza A/H1N1

Tamiflu significantly reduces the period of clinical manifestations of influenza infection, reduces the severity of the disease and reduces the incidence of complications of influenza, which require the use of antibiotics. It can also be used for prophylaxis of influenza, which led to a 92% significantly reduces the incidence of influenza among persons exposed to patients and by 76% - the frequency of clinically established during the influenza outbreak. The drug can be given to including children under the age of one year.

Tamiflu is indicated for the treatment of influenza caused by viruses types A and B in adults and children over 12 years, with duration of symptoms no more than two sutok.Tipichnye flu symptoms appear suddenly and include fever, cough, headache, marked weakness, muscle pain and sore throat.
Dosage: Assign an adult and children over 12 let.Priem should begin as early as possible, when the first symptoms zabolevaniya.Tamiflyu to ingest 75 mg 2 times a day (morning and evening), during meals, for 5 dney.Mozhno taken with food or without regard to meals. Admission during the meal or with a small amount of milk reduces the possibility of gastric diskomfort.Naryadu with Tamiflu, perhaps symptomatic of the appointment in order to facilitate certain forms of influenza, such as zharoponizhayuschih.Dazhe if you already feel much better, treatment should be brought to a conclusion that is to take all 10 capsules of Tamiflu within 5 days. If you forget to take, take the missed dose as soon as you remember about it, but no later than 2 hours before the next appointment. Then continue to take Tamiflu at the usual time. A double dose of Tamiflu should not be accepted. If you miss several doses in a row, consult vrachom.U patients with creatinine clearance above 30 ml / min to adjust the dose does not nuzhno.U patients with creatinine clearance <30 ml / min is recommended to reduce the dose of Tamiflu to 75 mg once daily for 5 days. In patients with renal insufficiency (creatinine clearance <10 mL / min) application of Tamiflu has not been studied, so when his appointment to be careful. Patients with lesions of the liver: a correction dose of Tamiflu is not trebuetsya.Bolnym old age: Tamiflu dosage adjustment is required.
Contra-indications: safety and efficacy of Tamiflu in children under 12 years of age ustanovleny.Vozmozhno during pregnancy if the expected effect of therapy outweighs the potential risk to the fetus and child health (adequate and strictly controlled studies of the safety of pregnant and lactating women have not performed, unknown if excreted oseltamivir and oseltamivir carboxylate in the breast milk of women).
Side effects: Nausea, vomiting, bronchitis, insomnia and golovokruzhenie.V most cases, these reactions do not require lifting preparata.Vozmozhny as diarrhea, abdominal pain, headache, weakness.
Guidance for children and pregnant women: Currently, data on the use of the drug during pregnancy is insufficient to assess the teratogenic effects or fetotoxicity of oseltamivir phosphate. With this in mind, Tamiflu should be prescribed during pregnancy or during lactation only if the anticipated benefits from its use outweighs the potential risk to the fetus or infant. In experimental studies of reproduction in rats and rabbits, teratogenic effects were observed. Instructions for any influence of any of the studied doses of oseltamivir on reproduction has been received. AUC of the drug in the embryos of rats and rabbits was approximately 15-20% of that of the pregnant females. In lactating rats, oseltamivir and active metabolite are allocated to milk. Provided whether oseltamivir or its active metabolite with milk in humans is unknown.
Cautions: The effectiveness of the treatment of patients with chronic heart and / or respiratory ustanovlena.Ne not observed differences in the incidence of complications between the groups receiving oseltamivir phosphate for treatment and the placebo group, in this category bolnyh.Net available information on treatment influenza in patients with severe health or conditions requiring hospitalization.

Profile of unwanted side effects in patients at risk was, in general, the same as in adult patients with younger age, without concomitant diseases.
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